Abstract
Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
MeSH terms
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Animals
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Anti-Arrhythmia Agents / chemistry*
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Anti-Arrhythmia Agents / pharmacology*
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Atrial Fibrillation / drug therapy
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Atrial Flutter / drug therapy
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Humans
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Kv1.5 Potassium Channel / antagonists & inhibitors*
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Potassium Channel Blockers / chemical synthesis
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Potassium Channel Blockers / chemistry*
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Potassium Channel Blockers / pharmacology*
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Rats
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Thiazolidines / chemical synthesis
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Thiazolidines / chemistry*
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Thiazolidines / pharmacology*
Substances
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Anti-Arrhythmia Agents
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KCNA5 protein, human
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Kv1.5 Potassium Channel
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Potassium Channel Blockers
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Thiazolidines